New imaging reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. Germinal centers are high-speed evolution ...

Trained immunity is reshaping our understanding of host defense by demonstrating that innate immune cells once thought to lack memory can be reprogrammed to mount heightened responses to subsequent ...

1 Department of Hematology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China 2 Harbin Medical University, Harbin, Heilongjiang, China Innate immune cells and ...

An investigational Toll-like receptor (TLR) antagonist was effective in reducing biomarkers and clinical symptoms of systemic lupus erythematosus (SLE) in a pilot trial, evidence that the innate ...

The House Oversight Committee, led by GOP Chairman James Comer, said it "will not consider" a request from Ghislaine Maxwell's attorneys seeking immunity in exchange for her testimony to Congress. The ...

In the past, immune memory was considered an exclusive feature of the adaptive immune system. However, accumulating evidence suggests that the innate immune system, the most primitive and fundamental ...

When your body senses something is wrong—whether it's a damaged cell or a growing tumor—it can react in many ways. One of the most powerful is cellular senescence. This process stops a cell from ...

Researchers have discovered that mRNA-based COVID-19 vaccines have a persistent effect on the innate immune system. These mechanisms may help the human body to better protect itself against potential ...

The immune-boosting power of a fever is surprisingly ancient. Cold-blooded creatures like fish typically move to warmer environments to help fight infections. In one fish species, Nile tilapia, that ...

A new review by Dr. Ruyuan Wang and an international team of researchers explores the complex interactions between the innate and adaptive immune systems, shedding light on regulatory mechanisms in ...

Our immune system is divided into two main branches: innate and adaptive. Innate immune cells act as a first line of defense, quickly responding to invaders, while adaptive immune cells take a longer ...