Here, we report a practical method for the fast and highly selective direct cross-coupling of organolithium reagents under mild conditions, and with broad scope, using Pd catalysis. Catalytic C–C bond ...

In past decades, catalytic cross-coupling reactions between organic halides and organometallic reagents to construct carbon–carbon bond have achieved a tremendous progress. However, organolithium ...

DIRECT CROSS-COUPLING of aryl halides with alkyl halides to form substituted aryl compounds—one of the most indispensable types of reactions in organic synthesis—has just gotten easier thanks to a new ...

If you’re a chemist working with peptide coupling agents, you can literally become allergic to the lab, according to a new report. Over the course of three years, graduate student Kate McKnelly of the ...

Non-precious-metal catalysts are increasingly employed for commercial API synthesis. Cross-coupling reactions enable the synthesis of complex building blocks and intermediates with structural motifs ...

In the ongoing search for better fluorinating reagents, solid reagents and new coupling reactions are showing promise. Fluorine atoms have a unique combination of electronic and physical properties.

Development of reliable multiplex assays on xMAP beads for serological or other assays, is not only dependent on proper coupling of capture molecules, it is also dependent on the proper mixing of ...

Oligonucleotides are short strands of DNA or RNA that play a major role in drug discovery and molecular diagnostic chip technology. They are used from initial research and screening through to target ...